- Pick up an undamaged ambulance from outside a medical centre preferable in the countryside or desert. Look around to make sure there are no cops watching (you don't want to do side missions with a wanted star)
- Before setting off to pick up passengers put up the map and work out the best way to collect them by travelling the shortest distance. Remember that the ambulance can only take 3 passengers.
- Keep track of the doors that passengers get in (two go in the back on in the side door). That way you can park so that the passengers have to walk the minimum distance.
- When stopping outside the medical centre press R1 and not square. That way you will stop in the red circle without reversing.
- When moving away from the medical centre don't worry about running people over.
Note: you cannot pay and spray an ambulance so be careful not to set it on fire. Also you will fail the mission for killing the people you should be picking up.